Control and Coordination
Easy Overview
Your body is doing a million things right now — breathing, balancing, blinking, digesting — and you're not thinking about any of it. That's because your nervous system and endocrine system handle everything behind the scenes. This chapter is about the control room (brain) and the messaging systems (nerves and hormones) that keep you alive. The nervous system is built from specialized cells called neurons. Each neuron has dendrites (receivers), a cell body (processor), an axon (wire), and axon terminals (output). The signal travels as an electrical impulse along the axon. In myelinated neurons, the signal jumps from node to node (saltatory conduction) — much faster than in unmyelinated neurons. When the signal reaches the end of a neuron, it crosses a tiny gap called the synapse. Neurotransmitters (chemical messengers) are released, float across the gap, and bind to receptors on the next neuron. Then the signal continues. Some drugs work by messing with this process. The brain has three main parts. The cerebrum is the biggest part — responsible for thinking, memory, voluntary movement, and sensation. The cerebellum handles balance and coordination. The brainstem (medulla) handles automatic stuff — heartbeat, breathing, digestion — the things you never think about. The brain uses 20% of your body's oxygen despite being only 2% of your weight. The spinal cord runs from the brainstem down the spine and serves as the information highway between the brain and the rest of the body. It's also the center for reflex actions. A reflex arc is the fastest response in the body. When you touch something hot, you pull your hand back before you even feel the pain. The signal goes from sensory neuron to spinal cord to motor neuron — straight back, no brain involvement. The brain gets the message a split second later as pain. This delay saves your skin from burning. The peripheral nervous system (PNS) connects the CNS to the rest of the body. It has two divisions: the somatic nervous system (voluntary control of skeletal muscles) and the autonomic nervous system (involuntary control of internal organs). The autonomic system has two branches: sympathetic (fight or flight — speeds up heart, dilates pupils, slows digestion) and parasympathetic (rest and digest — slows heart, constricts pupils, stimulates digestion). They work antagonistically to maintain balance. Sense organs are the windows to the world. The eye has a lens that focuses light onto the retina (where photoreceptors — rods for dim light, cones for color — convert light to nerve signals). The ear converts sound waves into nerve signals (in the cochlea) and helps maintain balance (through the vestibular apparatus). The endocrine system is the slow messenger. While nerves act in milliseconds, hormones act in seconds to hours but last longer. Glands like the pituitary (master gland), thyroid, parathyroid, adrenal, pancreas, and gonads release hormones into the blood. These chemical messengers travel everywhere but only affect cells with the right receptors. The hypothalamus controls the pituitary, which in turn controls other glands — this is the hypothalamic-pituitary axis. Feedback mechanisms maintain homeostasis. Negative feedback is most common: when blood sugar goes up, insulin is released to bring it down. When you're cold, shivering generates heat. Positive feedback is rarer — like during childbirth, oxytocin makes contractions stronger, which triggers more oxytocin, until the baby is born.
The neuron — your body's text message
Neurons are specialized cells that transmit electrical signals. Structure: dendrites (short, branched — receive signals), cell body (contains nucleus and organelles), axon (long, single fiber — conducts impulse away), axon terminals (release neurotransmitters). Myelinated neurons have a myelin sheath (formed by Schwann cells in PNS, oligodendrocytes in CNS) that insulates the axon. Gaps between myelin segments are nodes of Ranvier. Saltatory conduction: impulse jumps from node to node, increasing speed up to 50x compared to unmyelinated axons. Based on function: sensory (afferent), motor (efferent), and interneurons.
Nerve impulse transmission — the action potential
At rest, a neuron has a resting membrane potential of about -70 mV (inside negative relative to outside). This is maintained by the Na+/K+ pump (3 Na+ out, 2 K+ in) and selective permeability. When stimulated, voltage-gated Na+ channels open, Na+ rushes in, and the membrane depolarizes (becomes positive — up to +40 mV). This is the action potential. Then K+ channels open, K+ leaves, repolarizing the membrane. The Na+/K+ pump restores the resting potential. The action potential travels down the axon without decreasing (unlike a normal electrical signal). The refractory period ensures one-way travel.
Synaptic transmission — crossing the gap
Neurons communicate across synapses. When an action potential reaches the presynaptic terminal, voltage-gated Ca2+ channels open. Ca2+ influx causes synaptic vesicles (containing neurotransmitters) to fuse with the membrane and release their contents into the synaptic cleft. Neurotransmitters diffuse across and bind to receptors on the postsynaptic membrane. This opens ion channels, causing either excitation (EPSP — depolarization) or inhibition (IPSP — hyperpolarization). The signal is terminated by enzyme breakdown (acetylcholinesterase breaks down ACh) or reuptake. Drugs like cocaine and SSRI antidepressants affect neurotransmitter reuptake.
The brain — the CEO
The brain is divided into three main parts. (1) Cerebrum (largest, 80% of brain mass): divided into two hemispheres connected by corpus callosum; has four lobes — frontal (motor, personality, speech), parietal (sensory, spatial), temporal (auditory, memory), occipital (vision). Outer layer is cerebral cortex (grey matter — neuron cell bodies). (2) Cerebellum (hindbrain): coordinates voluntary movements, balance, and posture. (3) Brainstem (medulla oblongata, pons, midbrain): controls automatic functions — breathing, heart rate, blood pressure, digestion. The brain uses 20% of body's oxygen and glucose despite being only 2% of body weight.
Reflex arc — act first, think later
A reflex is an automatic, rapid response to a stimulus that bypasses the brain. The reflex arc pathway: (1) Receptor detects stimulus. (2) Sensory neuron carries impulse to spinal cord. (3) Interneuron (in spinal cord) relays signal. (4) Motor neuron carries impulse to effector. (5) Effector (muscle) responds. The brain gets the signal slightly later — that's why you pull your hand from a hot stove before you feel the pain. Examples: knee-jerk reflex (patellar), withdrawal reflex (hand on hot object), blinking reflex. Reflexes are protective mechanisms that reduce response time.
Spinal cord and peripheral nerves
The spinal cord extends from the medulla to the lumbar region. It has an inner H-shaped grey matter (neuron cell bodies) and outer white matter (myelinated axons forming tracts). Ascending tracts carry sensory info to the brain; descending tracts carry motor commands from the brain. Spinal nerves (31 pairs) emerge from the cord. The peripheral nervous system (PNS) includes cranial nerves (12 pairs — from brain) and spinal nerves. The PNS has two divisions: somatic (voluntary, controls skeletal muscles) and autonomic (involuntary, controls internal organs).
Autonomic nervous system — fight or flight vs rest and digest
The autonomic nervous system (ANS) has two antagonistic branches. Sympathetic: prepares the body for stress — increases heart rate and breathing, dilates pupils, inhibits digestion, redirects blood to muscles. Uses norepinephrine as neurotransmitter. Preganglionic fibers are short, postganglionic long. Parasympathetic: conserves energy — slows heart rate, constricts pupils, stimulates digestion, promotes rest. Uses acetylcholine as neurotransmitter. Preganglionic fibers are long, postganglionic short. Most organs receive both sympathetic and parasympathetic input (dual innervation) for fine-tuned control.
Sense organs — the eye
The human eye works like a camera. Light enters through the cornea (bends light), passes through the pupil (opening in iris — controls light amount), then the lens (focuses light onto retina). The ciliary muscles change lens shape (accommodation) for near or far vision. The retina contains photoreceptors: rods (about 120 million — sensitive to dim light, black and white) and cones (about 6 million — color vision, three types for red, green, blue). The fovea has the highest concentration of cones for sharp vision. Signals travel via optic nerve to the brain. The blind spot has no photoreceptors.
Sense organs — the ear
The ear has three parts. Outer ear: pinna (collects sound) and auditory canal. Middle ear: tympanic membrane (eardrum) vibrates, three ossicles (malleus, incus, stapes) amplify and transmit vibrations to the oval window. Inner ear: cochlea (hearing) and vestibular apparatus (balance). In the cochlea, fluid waves stimulate hair cells on the basilar membrane, converting mechanical vibrations to nerve signals (organ of Corti). Different frequencies stimulate different parts of the basilar membrane. The vestibular apparatus (semicircular canals, utricle, saccule) detects head position and movement for balance.
Endocrine system — the slow messenger
Endocrine glands secrete hormones directly into the blood. Major glands: (1) Hypothalamus — links nervous and endocrine systems; controls pituitary. (2) Pituitary (master gland) — anterior lobe secretes GH, TSH, ACTH, FSH, LH, prolactin, MSH; posterior lobe releases oxytocin and ADH. (3) Thyroid — T3 and T4 regulate metabolism; calcitonin lowers blood calcium. (4) Parathyroid — PTH raises blood calcium. (5) Adrenal — cortex (cortisol, aldosterone, sex hormones), medulla (adrenaline, noradrenaline). (6) Pancreas — insulin (lowers blood glucose), glucagon (raises blood glucose). (7) Gonads — estrogen, progesterone, testosterone.
Hormone action — how hormones work
Hormones are classified by chemical nature. Peptide hormones (insulin, GH, prolactin): water-soluble, cannot cross cell membrane, bind to surface receptors, activate second messengers (cAMP, IP3, Ca2+) via G-proteins. Steroid hormones (cortisol, aldosterone, sex hormones): lipid-soluble, cross cell membrane, bind to intracellular receptors, act directly on DNA to regulate gene expression — slower but longer lasting. Amine hormones (adrenaline, T3/T4): derived from tyrosine; adrenaline acts via surface receptors, thyroid hormones enter cells and act on nuclear receptors.
Feedback mechanisms — keeping things steady
Homeostasis is maintained mainly by negative feedback. Example: blood glucose regulation. After eating, blood glucose rises, pancreas releases insulin, cells take up glucose, liver stores glycogen, blood glucose falls. When blood glucose falls too low, pancreas releases glucagon, liver breaks down glycogen, blood glucose rises. This is negative feedback — the response reverses the initial change. Positive feedback amplifies change. Examples: childbirth (oxytocin increases contractions, which stimulates more oxytocin until delivery), blood clotting (platelet aggregation triggers more aggregation), and action potential generation (depolarization opens more Na+ channels).
Endocrine disorders — when hormones go wrong
Disorders arise from hormone excess or deficiency. (1) Diabetes mellitus: Type 1 (insulin deficiency — autoimmune destruction of beta cells, requires insulin injections) and Type 2 (insulin resistance — linked to obesity, managed with diet, exercise, medications). (2) Hypothyroidism (low thyroid hormones — fatigue, weight gain, cold intolerance) and Hyperthyroidism (excess — weight loss, heat intolerance, bulging eyes in Graves disease). (3) Dwarfism (GH deficiency in childhood) and Gigantism (GH excess in childhood). (4) Addison's disease (cortisol deficiency) and Cushing's syndrome (cortisol excess). (5) Goiter (enlarged thyroid due to iodine deficiency).
Key Points
- •Neuron: dendrites, cell body, axon, synaptic terminals; signal travels dendrite to axon
- •Myelinated neurons have faster saltatory conduction (signal jumps at nodes of Ranvier)
- •Action potential: Na+ influx (depolarization) then K+ efflux (repolarization); all-or-none response
- •Synapse: neurotransmitters released from presynaptic neuron bind to receptors on postsynaptic
- •Brain: cerebrum (conscious thought, voluntary movement), cerebellum (coordination), medulla (autonomic)
- •Reflex arc: sensory neuron to spinal interneuron to motor neuron (bypasses brain for speed)
- •Spinal cord: ascending (sensory) and descending (motor) tracts; 31 pairs of spinal nerves
- •PNS: somatic (voluntary) and autonomic (involuntary) nervous systems
- •Autonomic: sympathetic (fight or flight) — norepinephrine; parasympathetic (rest and digest) — acetylcholine
- •Eye: cornea, lens, retina (rods for dim light, cones for color), optic nerve
- •Ear: outer (pinna, canal), middle (ossicles), inner (cochlea for hearing, vestibular for balance)
- •Pituitary is the master gland controlled by hypothalamus; secretes 8 hormones
- •Peptide hormones: bind surface receptors, act via second messengers (fast) — insulin, GH
- •Steroid hormones: cross membrane, bind intracellular receptors, regulate gene expression (slow) — sex hormones, cortisol
- •Negative feedback maintains homeostasis (insulin/glucagon, temperature regulation)
- •Positive feedback amplifies change (childbirth, blood clotting, action potential)
- •Diabetes: Type 1 (insulin deficiency), Type 2 (insulin resistance); both cause high blood glucose
- •Disorders: hypo/hyperthyroidism, dwarfism/gigantism, Addison/Cushing, goiter
Practice Questions
- Draw and label a neuron. Explain how an action potential travels along it.
- What happens at a synapse? How do neurotransmitters carry the signal across the gap?
- Describe the structure and functions of the cerebrum, cerebellum, and medulla oblongata.
- What is a reflex arc? Give an example and explain why it bypasses the brain.
- Distinguish between sympathetic and parasympathetic nervous systems with examples.
- Describe the structure of the human eye. How does it focus light and convert it to nerve signals?
- Name the major endocrine glands and their hormones. What is the role of the pituitary?
- Explain negative feedback with the example of blood glucose regulation by insulin and glucagon.